Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from F344N rats in long and short photoperiods


ABSTRACT: Rats were housed in either long day (LD, 16:8 hours, light:dark) or short day (SD, 8:16 hours, light dark) photoperiods for 3, 14 and 28 days and brains removed, frozen on dry ice and then hypothalamic arcuate nucleus tissue blocks cut for RNA extraction. At each time point 4 rats were used in each photoperiod giving 24 rats in total. RNA from each rat was used on separate affymetrix rat 230 2.0 arrays, using 24 in total. Comparison of expression of genes were made between rats from each photoperiod at 3, 14 and 28 day timepoints.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Alexander Ross 

PROVIDER: E-GEOD-27926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Thyroid hormone signalling genes are regulated by photoperiod in the hypothalamus of F344 rats.

Ross Alexander W AW   Helfer Gisela G   Russell Laura L   Darras Veerle M VM   Morgan Peter J PJ  

PloS one 20110622 6


Seasonal animals adapt their physiology and behaviour in anticipation of climate change to optimise survival of their offspring. Intra-hypothalamic thyroid hormone signalling plays an important role in seasonal responses in mammals and birds. In the F344 rat, photoperiod stimulates profound changes in food intake, body weight and reproductive status. Previous investigations of the F344 rat have suggested a role for thyroid hormone metabolism, but have only considered Dio2 expression, which was e  ...[more]

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