Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide CTCF binding maps in mouse ES and fibroblast cells


ABSTRACT: Chromatin immunoprecipitation against CTCF followed by Illumina High-throughput sequencing. Examination of CTCF binding in embryonic stem cells and embryonic fibroblasts

ORGANISM(S): Mus musculus

SUBMITTER: David Martin 

PROVIDER: E-GEOD-27944 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Many genomic alterations associated with human diseases localize in noncoding regulatory elements located far from the promoters they regulate, making it challenging to link noncoding mutations or risk-associated variants with target genes. The range of action of a given set of enhancers is thought to be defined by insulator elements bound by the 11 zinc-finger nuclear factor CCCTC-binding protein (CTCF). Here we analyzed the genomic distribution of CTCF in various human, mouse and chicken cell  ...[more]

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