Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Martin
PROVIDER: E-GEOD-27944 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Martin David D Pantoja Cristina C Fernández Miñán Ana A Valdes-Quezada Christian C Moltó Eduardo E Matesanz Fuencisla F Bogdanović Ozren O de la Calle-Mustienes Elisa E Domínguez Orlando O Taher Leila L Furlan-Magaril Mayra M Alcina Antonio A Cañón Susana S Fedetz María M Blasco María A MA Pereira Paulo S PS Ovcharenko Ivan I Recillas-Targa Félix F Montoliu Lluís L Manzanares Miguel M Guigó Roderic R Serrano Manuel M Casares Fernando F Gómez-Skarmeta José Luis JL
Nature structural & molecular biology 20110522 6
Many genomic alterations associated with human diseases localize in noncoding regulatory elements located far from the promoters they regulate, making it challenging to link noncoding mutations or risk-associated variants with target genes. The range of action of a given set of enhancers is thought to be defined by insulator elements bound by the 11 zinc-finger nuclear factor CCCTC-binding protein (CTCF). Here we analyzed the genomic distribution of CTCF in various human, mouse and chicken cell ...[more]