Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dieter Egli
PROVIDER: E-GEOD-28022 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Noggle Scott S Fung Ho-Lim HL Gore Athurva A Martinez Hector H Satriani Kathleen Crumm KC Prosser Robert R Oum Kiboong K Paull Daniel D Druckenmiller Sarah S Freeby Matthew M Greenberg Ellen E Zhang Kun K Goland Robin R Sauer Mark V MV Leibel Rudolph L RL Egli Dieter D
Nature 20111005 7367
The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. Here we report that the development of human oocytes after genome exchange arrests at late cleavage stages in association with transcriptional abnormalities. In contrast, if the oocyte genome is not removed ...[more]