Dataset Information
A comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants (GenomeWideSNP_6)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dalila Pinto
PROVIDER: E-GEOD-28111 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants.
Nature biotechnology 20110508 6
We have systematically compared copy number variant (CNV) detection on eleven microarrays to evaluate data quality and CNV calling, reproducibility, concordance across array platforms and laboratory sites, breakpoint accuracy and analysis tool variability. Different analytic tools applied to the same raw data typically yield CNV calls with <50% concordance. Moreover, reproducibility in replicate experiments is <70% for most platforms. Nevertheless, these findings should not preclude detection of ...[more]
