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Regulatory T cells

ABSTRACT: Induced and activated regulatory CD4+ Foxp3+ cells compared Conventional naive CD4+ T cells were sorted and converted in vitro into adaptive Treg cells, activated Treg cells were generated in vitro from sorted Foxp3GFP+ cells

ORGANISM(S): Mus musculus

SUBMITTER: Piotr Kraj

PROVIDER: E-GEOD-28130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells.

Kuczma Michal M Lee Jeffrey R JR Kraj Piotr P

Journal of immunology (Baltimore, Md. : 1950) 20110603 1

Despite their importance for the functioning of the immune system, thymic development and peripheral maintenance of Foxp3(+) regulatory T (T(R)) cells are poorly understood. We have found that connexin 43 (Cx43), expressed by thymic T(R) cells progenitors, supports T(R) development. Mice with deletion of the Cx43 gene induced in T cells produce only few T(R) cells and had increased proportion of activated T cells in the lymph nodes, suggesting impaired peripheral tolerance. Reduction of the T(R) ...[more]

PMID: 21642545

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