L3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-chip data].

ABSTRACT: Human  MBT  domain‐containing  protein  L3MBTL2  was  found  to  be  an  integral  component  of   a  protein  complex  that  we  termed  Polycomb  Repressive  Complex  1‐like  3  (PRC1L3)  given  the  presence   of  the  PcG  proteins  RING1,  RING2  and  PCGF6.  L3MBTL2  binds  chromatin  in  a  histone  modification‐ independent  manner  and  is  required  for  the  repressive  function  of  PRC1L3.  PRC1L3  also  contains  E2F6   and  CBX3,  two  factors  with  well‐established  functions  in  transcriptional  repression.  Genome‐wide   profiling  identified  several  hundred  genes  that  are  simultaneously  bound  by  L3MBTL2  and  E2F6,   preferentially  around  transcriptional  start  sites.  Importantly,  these  genes  are  largely  distinct  from   those  targeted  by  other  E2

ORGANISM(S): Homo sapiens

SUBMITTER: Victor Jin 

PROVIDER: E-GEOD-28161 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress