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Melanoma cell culture phenotypes

ABSTRACT: Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding patients experience disease relapse. We describe here how melanoma cells respond to MAPK inhibition in a phenotype-specific manner, suggesting that slow cycling invasive phenotype cells provide a treatment-resistant pool from which disease relapse may be derived. The implication is that while MAPK inhibition may successfully treat proliferating cells, another cell population needs to be addressed at the same time. 12 samples

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Widmer

PROVIDER: E-GEOD-28335 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status.

Zipser Marie C MC Eichhoff Ossia M OM Widmer Daniel S DS Schlegel Natalie C NC Schoenewolf Nicola L NL Stuart Darrin D Liu Weihua W Gardner Humphrey H Smith Paul D PD Nuciforo Paolo P Dummer Reinhard R Hoek Keith S KS

Pigment cell & melanoma research 20110112 2

Oncogenic mutations within the MAPK pathway are frequent in melanoma, and targeting of MAPK signaling has yielded spectacular responses in a significant number of patients that last for several months before relapsing. We investigated the effects of two different inhibitors of MAPK signaling in proliferative and invasive melanoma cell cultures with various mutations in the MAPK pathway. Proliferative melanoma cells were more susceptible to pathway inhibition than invasive phenotype cells, irresp ...[more]

PMID: 21176117

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Melanoma cell culture phenotypes I

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2011-04-05 | GSE28335 | GEO

Melanoma cell culture phenotypes II

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Melanoma cell culture phenotypes

Project description:This SuperSeries is composed of the following subset Series: GSE28335: Melanoma cell culture phenotypes I GSE33727: Melanoma cell culture phenotypes II Refer to individual Series

2011-11-17 | E-GEOD-33728 | biostudies-arrayexpress

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The effect of MEK inhibition on transcription in melanoma [Batch 2]

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