Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrew Rice
PROVIDER: E-GEOD-28339 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ramakrishnan Rajesh R Yu Wendong W Rice Andrew P AP
BMC research notes 20110726
<h4>Background</h4>The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation phase. P-TEFb contains Cdk9 (Cyclin-dependent kinase 9) as its catalytic subunit and is regulated by its Cyclin partners, Cyclin T1 and Cyclin T2. The HIV-1 Tat transactivator protein enhances viral gene expression by exclusively recruiting ...[more]