Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Walker
PROVIDER: E-GEOD-28359 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boitano Anthony E AE Wang Jian J Romeo Russell R Bouchez Laure C LC Parker Albert E AE Sutton Sue E SE Walker John R JR Flaveny Colin A CA Perdew Gary H GH Denison Michael S MS Schultz Peter G PG Cooke Michael P MP
Science (New York, N.Y.) 20100805 5997
Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Mechanistic studie ...[more]