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Expression data from ALL diagnosis and relapse pediatric acute lymphoblastic leukemia cases

ABSTRACT: There is a distinct signature of differentially expressed probes from diagnosis to relapse Gene expression profiles of pediatric patients with B-precursor ALL were compared to at 2 time points, diagnosis and relapse. The overall design was a comparison of gene expression at diagnosis and relapse within individual patients. A subset analysis (comparing diagnosis to relapse expression within individuals), was done for early relapse (less than 36 months) cases only and late relapse (greater than 36 months) cases only.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Hogan

PROVIDER: E-GEOD-28460 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.

Hogan Laura E LE Meyer Julia A JA Yang Jun J Wang Jinhua J Wong Nicholas N Yang Wenjian W Condos Gregory G Hunger Stephen P SP Raetz Elizabeth E Saffery Richard R Relling Mary V MV Bhojwani Deepa D Morrison Debra J DJ Carroll William L WL

Blood 20110914 19

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the outcome after relapse is poor. To understand the genetic events that contribute to relapse and chemoresistance and identify novel targets of therapy, 3 high-throughput assays were used to identify genetic and epigenetic changes at relapse. Using matched diagnosis/relapse bone marrow samples from children with relapsed B-precursor ALL, we evaluated gene expression, copy number abnormalities (CNAs), and DNA m ...[more]

PMID: 21921043

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