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Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

ABSTRACT: Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations. We compared gene expression profiles of AA with (n: 3) and without (n: 4) CTNNB1 mutations using Affymetrix arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: julien durand

PROVIDER: E-GEOD-28476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

Durand Julien J Lampron Antoine A Mazzuco Tania L TL Chapman Audrey A Bourdeau Isabelle I

The Journal of clinical endocrinology and metabolism 20110511 7

<h4>Background</h4>Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and adrenocortical carcinomas (ACC). However, the target genes of β-catenin have not yet been identified in adrenocortical tumors.<h4>Objective</h4>Our objective was to identify genes deregulated in adrenocortical tumors harboring CTNNB1 genetic alterations and nuclear accumulation of β-catenin.<h4>Methods</h4>Microarray analysis identified a dataset of genes that were differently expressed betwe ...[more]

PMID: 21565795

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Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

Project description:Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.

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