Unknown,Transcriptomics,Genomics,Proteomics

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Listeria monocytogenes transcriptional response to bile


ABSTRACT: These studies were designed to examine the acute Listeria monocytogenes transcriptional response to mammalian (porcine) bile. Triplicate WT Listeria monocytogenes (strain 10403S) were grown to mid-log in BHI at 37 °C. Samples were divided, and either treated or not treated by addition of porcine bile (Sigma, to 1% final) for 30 minutes.

ORGANISM(S): Listeria monocytogenes

SUBMITTER: Jess Leber 

PROVIDER: E-GEOD-28507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The novel Listeria monocytogenes bile sensor BrtA controls expression of the cholic acid efflux pump MdrT.

Quillin Sarah J SJ   Schwartz Kierstyn T KT   Leber Jess H JH  

Molecular microbiology 20110523 1


Mammalian bile has potent anti-microbial activity, yet bacterial pathogens of the gastrointestinal tract and hepatobiliary system nonetheless persist and replicate within bile-rich environments. Listeria monocytogenes, a Gram-positive pathogen, encounters bile at three stages throughout its infectious cycle in vivo: in the gut during initial infection, in the liver where it replicates robustly and in the gallbladder, from which it can return to the intestine and thence to the environment. The me  ...[more]

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