Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Per Stenberg
PROVIDER: E-GEOD-28513 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Johansson Anna-Mia AM Stenberg Per P Allgardsson Anders A Larsson Jan J
Molecular and cellular biology 20120402 11
In Drosophila, two chromosome-wide compensatory systems have been characterized: the dosage compensation system that acts on the male X chromosome and the chromosome-specific regulation of genes located on the heterochromatic fourth chromosome. Dosage compensation in Drosophila is accomplished by hypertranscription of the single male X chromosome mediated by the male-specific lethal (MSL) complex. The mechanism of this compensation is suggested to involve enhanced transcriptional elongation medi ...[more]