Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Danilo Licastro
PROVIDER: E-GEOD-28575 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of cell science 20130322 Pt 10
Overexpression of facioscapulohumeral muscular dystrophy region gene 1 (FRG1) in mice, frogs and worms leads to muscular and vascular abnormalities. Nevertheless, the mechanism that follows FRG1 overexpression and finally leads to muscular defects is currently unknown. Here, we show that the earliest phenotype displayed by mice overexpressing FRG1 is a postnatal muscle-growth defect. Long before the development of muscular dystrophy, FRG1 mice also exhibit a muscle regeneration impairment. Ex vi ...[more]