Development of gene expression signatures on immunity for bursal peptide BPP-II
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ABSTRACT: To further elucidate the mechanism of BPP-II on immunity on the broad molecular level, we have employed whole genome microarray expression profiling as a discovery platform to examine gene expression patterns during BPP-II treatment in a mouse derived hybridoma culture system. Hybridoma cell was treated ex vivo, and robust normalization of the data identified 2478 differentially expressed probe sets exhibiting minimum 1.5-fold changes that distinguished between BPP-II and control samples. Various pathwayswere significantly impacted by BPP-II treatment, and gene Ontology annotations show changes in the expression of molecules involved in immune and immunocyte related cellular processes. Expression of 8 genes (MS4A2M-oM-
ORGANISM(S): Mus musculus
SUBMITTER: Pu Chen
PROVIDER: E-GEOD-28696 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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