Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Charles Mullighan
PROVIDER: E-GEOD-28703 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gutierrez Alejandro A Kentsis Alex A Sanda Takaomi T Holmfeldt Linda L Chen Shann-Ching SC Zhang Jianhua J Protopopov Alexei A Chin Lynda L Dahlberg Suzanne E SE Neuberg Donna S DS Silverman Lewis B LB Winter Stuart S SS Hunger Stephen P SP Sallan Stephen E SE Zha Shan S Alt Frederick W FW Downing James R JR Mullighan Charles G CG Look A Thomas AT
Blood 20110830 15
The BCL11B transcription factor is required for normal T-cell development, and has recently been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) induced by TLX overexpression or Atm deficiency. To comprehensively assess the contribution of BCL11B inactivation to human T-ALL, we performed DNA copy number and sequencing analyses of T-ALL diagnostic specimens, revealing monoallelic BCL11B deletions or missense mutations in 9% (n = 10 of 117) of cases. Structural homolo ...[more]