Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from cultured human ovarian carcinoma cell lines

ABSTRACT: The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted RNA of 34 cultured human ovarian carcinoma cell lines and performed expression microarrays so that cultured cell lines can represent in vivo human tumors. 34 ovarian carcinoma cell lines expression data.

ORGANISM(S): Homo sapiens

SUBMITTER: Tuan Zea Tan 

PROVIDER: E-GEOD-28724 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To address this heterogeneity, a classification scheme was developed based on gene expression patterns of 1538 tumours. Five, biologically distinct subgroups - Epi-A, Epi-B, Mes, Stem-A and Stem-B - exhibited significantly distinct clinicopathological characteristics, deregulated pathways and patient prognoses, and were validated using independent datasets. To identify subtype-specific molecular targets, ovarian can  ...[more]

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