Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kern Rei Chng
PROVIDER: E-GEOD-28951 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chng Kern Rei KR Chang Cheng Wei CW Tan Si Kee SK Yang Chong C Hong Shu Zhen SZ Sng Noel Yan Wei NY Cheung Edwin E
The EMBO journal 20120424 12
Transcriptional corepressors are frequently aberrantly over-expressed in prostate cancers. However, their crosstalk with the Androgen receptor (AR), a key player in prostate cancer development, is unclear. Using ChIP-Seq, we generated extensive global binding maps of AR, ERG, and commonly over-expressed transcriptional corepressors including HDAC1, HDAC2, HDAC3, and EZH2 in prostate cancer cells. Surprisingly, our results revealed that ERG, HDACs, and EZH2 are directly involved in androgen-regul ...[more]