Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Matt Thomson
PROVIDER: E-GEOD-29005 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20110601 6
Cell fate decisions are fundamental for development, but we do not know how transcriptional networks reorganize during the transition from a pluripotent to a differentiated cell state. Here, we asked how mouse embryonic stem cells (ESCs) leave the pluripotent state and choose between germ layer fates. By analyzing the dynamics of the transcriptional circuit that maintains pluripotency, we found that Oct4 and Sox2, proteins that maintain ESC identity, also orchestrate germ layer fate selection. O ...[more]