Knockout of heterotrimeric signaling G protein beta5 impaires brain development and causes severe neurologic dysfunction in mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: WeiPing Chen
PROVIDER: E-GEOD-29083 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.
Zhang Jian-Hua JH Pandey Mritunjay M Seigneur Erica M EM Panicker Leelamma M LM Koo Lily L Schwartz Owen M OM Chen Weiping W Chen Ching-Kang CK Simonds William F WF
Journal of neurochemistry 20110923 3
Gβ5 is a divergent member of the signal-transducing G protein β subunit family encoded by GNB5 and expressed principally in brain and neuronal tissue. Among heterotrimeric Gβ isoforms, Gβ5 is unique in its ability to heterodimerize with members of the R7 subfamily of the regulator of G protein signaling proteins that contain G protein-γ like domains. Previous studies employing Gnb5 knockout (KO) mice have shown that Gβ5 is an essential stabilizer of such regulator of G protein signaling proteins ...[more]
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