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ChimeraScan: A tool for identifying chimeric transcription in sequencing data

ABSTRACT: Next Generation Sequencing technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts. Three cancer cell lines with known gene fusions

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Iyer

PROVIDER: E-GEOD-29098 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ChimeraScan: a tool for identifying chimeric transcription in sequencing data.

Iyer Matthew K MK Chinnaiyan Arul M AM Maher Christopher A CA

Bioinformatics (Oxford, England) 20110811 20

<h4>Summary</h4>Next generation sequencing (NGS) technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts in high-throughput transcriptome sequencing data.<h4>Availability</h4>http://chimerascan.googlecode.com<h4>Contact</h4>cmaher@dom.wustl.edu<h4>Supplementary information</h4>Supplement ...[more]

PMID: 21840877

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