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5q21 tiling array on prostate tumors

ABSTRACT: CGH profiles of prostate tumors on custom designed high resolution arrays tiling chromosome 5q21 A custom high-density Agilent 15k CGH array tiling 5q21 was designed to narrow down the region of deletion at 5q21 to a few genes that could be followed up with functional studies. 8 critical prostate tumors samples with the most focal regions of deletion were chosen to be profiled on the 5q21 tiling array.

ORGANISM(S): Homo sapiens

SUBMITTER: Stephanie Huang

PROVIDER: E-GEOD-29228 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.

Huang S S Gulzar Z G ZG Salari K K Lapointe J J Brooks J D JD Pollack J R JR

Oncogene 20111219 37

Though prostate cancer is often indolent, it is nonetheless a leading cause of cancer death. Defining the underlying molecular genetic alterations may lead to new strategies for prevention or treatment. Towards this goal, we performed array-based comparative genomic hybridization (CGH) on 86 primary prostate tumors. Among the most frequent alterations not associated with a known cancer gene, we identified focal deletions within 5q21 in 15 out of 86 (17%) cases. By high-resolution tiling array CG ...[more]

PMID: 22179824

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