Unknown,Transcriptomics,Genomics,Proteomics

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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE29146: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP] GSE29147: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi] GSE29148: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO] GSE29150: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: kaifu chen 

PROVIDER: E-GEOD-29305 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

Kuo Alex J AJ   Cheung Peggie P   Chen Kaifu K   Zee Barry M BM   Kioi Mitomu M   Lauring Josh J   Xi Yuanxin Y   Park Ben Ho BH   Shi Xiaobing X   Garcia Benjamin A BA   Li Wei W   Gozani Or O  

Molecular cell 20111101 4


The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enzyme influences chromatin biology and myeloma pathogenesis. Here, we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2. Catalysis of H  ...[more]

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