Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yuji Nakai
PROVIDER: E-GEOD-29313 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Huang Lin L Nakai Yuji Y Kuwahara Iku I Matsumoto Ken K
Cancer research 20120112 5
Ewing sarcoma family tumors (ESFT) are highly aggressive and highly metastatic tumors caused by a chromosomal fusion between the Ewing sarcoma protein (EWS) with the transcription factor FLI-1. However, expression of the EWS/FLI-1 chimeric oncogene by itself is insufficient for carcinogenesis, suggesting that additional events are required. Here, we report the identification of the Akt substrate PRAS40 as an EWS target gene. EWS negatively regulates PRAS40 expression by binding the 3' untranslat ...[more]