Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Frank Kramer
PROVIDER: E-GEOD-29405 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hummon Amanda B AB Pitt Jason J JJ Camps Jordi J Emons Georg G Skube Susan B SB Huppi Konrad K Jones Tamara L TL Beissbarth Tim T Kramer Frank F Grade Marian M Difilippantonio Michael J MJ Ried Thomas T Caplen Natasha J NJ
Molecular cancer 20120104
<h4>Background</h4>Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells can be used to further understand the cellular processes cancer cells depend upon for survival.<h4>Results</h4>A small-scale RNAi screen of ~400 genes conducted in SW480 CRC cells identified several candidate genes as required for the viability of CRC cells, most prominentl ...[more]