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Gene expression profile of keloid tissue

ABSTRACT: Comparison of keloid to normal tissue One sample for each type of tissue examined

ORGANISM(S): Homo sapiens

SUBMITTER: Motoko Naitoh

PROVIDER: E-GEOD-2945 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage.

Naitoh Motoko M Kubota Hiroshi H Ikeda Mika M Tanaka Toshinori T Shirane Hirofumi H Suzuki Shigehiko S Nagata Kazuhiro K

Genes to cells : devoted to molecular & cellular mechanisms 20051101 11

Keloids are a dermal fibrotic disease whose etiology remains totally unknown and for which there is no successful treatment. Here, we employed cDNA microarray analysis to examine gene expression in keloid lesions and control skin. We found that 32 genes among the 9000 tested were strongly up-regulated in keloid lesions, of which 21 were confirmed by Northern blotting. These included at least seven chondrocyte/osteoblast marker genes, and RT-PCR analysis revealed that transcription factors specif ...[more]

PMID: 16236136

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