Transcriptome analysis of OECM1 after expression of let-7i
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Muh-Hwa Yang
PROVIDER: E-GEOD-29539 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
RAC1 activation mediates Twist1-induced cancer cell migration.
Yang Wen-Hao WH Lan Hsin-Yi HY Huang Chi-Hung CH Tai Shyh-Kuan SK Tzeng Cheng-Hwai CH Kao Shou-Yen SY Wu Kou-Juey KJ Hung Mien-Chie MC Yang Muh-Hwa MH
Nature cell biology 20120311 4
Epithelial-mesenchymal transition (EMT), which is characterized by the suppression of the adhesion protein E-cadherin, is a crucial process that promotes metastasis and stem-like properties of cancer cells. However, the dissociation of cellular aggregates is not sufficient to explain why cancer cells move, and the motile nature of cancer cells undergoing EMT remains elusive. Here, we identify a mechanism in which the EMT inducer Twist1 elicits cancer cell movement through activation of RAC1. Twi ...[more]
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