Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrew Weng
PROVIDER: E-GEOD-29959 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Medyouf Hind H Gusscott Samuel S Wang Hongfang H Tseng Jen-Chieh JC Wai Carol C Nemirovsky Oksana O Trumpp Andreas A Pflumio Francoise F Carboni Joan J Gottardis Marco M Pollak Michael M Kung Andrew L AL Aster Jon C JC Holzenberger Martin M Weng Andrew P AP
The Journal of experimental medicine 20110801 9
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer of immature T cells that often shows aberrant activation of Notch1 and PI3K-Akt pathways. Although mutations that activate PI3K-Akt signaling have previously been identified, the relative contribution of growth factor-dependent activation is unclear. We show here that pharmacologic inhibition or genetic deletion of insulin-like growth factor 1 receptor (IGF1R) blocks the growth and viability of T-ALL cells, whereas moderate dimi ...[more]