Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kevin Becker
PROVIDER: E-GEOD-29984 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Birkenfeld Andreas L AL Lee Hui-Young HY Guebre-Egziabher Fitsum F Alves Tiago C TC Jurczak Michael J MJ Jornayvaz Francois R FR Zhang Dongyang D Hsiao Jennifer J JJ Martin-Montalvo Alejandro A Fischer-Rosinsky Antje A Spranger Joachim J Pfeiffer Andreas F AF Jordan Jens J Fromm Martin F MF König Jörg J Lieske Stefanie S Carmean Christopher M CM Frederick David W DW Weismann Dirk D Knauf Felix F Irusta Pablo M PM De Cabo Rafael R De Cabo Rafael R Helfand Stephen L SL Samuel Varman T VT Shulman Gerald I GI
Cell metabolism 20110801 2
Reduced expression of the Indy (I'm Not Dead, Yet) gene in D. melanogaster and its homolog in C. elegans prolongs life span and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which Indy does this is unknown. Here, we report on the knockout mouse model of the mammalian Indy (mIndy) homolog, SLC13A5. Deletion of mIndy in mice (mINDY(-/-) mice) reduces hepatocellular ATP/ADP ratio, activates hepatic AMPK, induces PGC- ...[more]