Molecular mechanism of DNA minor groove binding ligand as a radiation modulator
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ABSTRACT: Radiation-induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. This study reports the expression analysis in response to DNA minor groove binding ligand (DMA-5-(4-methylpiperazin-1-yl)-2-[2’-(3,4-dimethoxyphenyl)-5`-benzimidazolyl] benzimidazole, an analogue of Hoechst 33342), with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation. Four different types of samples were employed in the analysis: Control (untreated) cells, 50µM ligand-treated cells, 2Gy radiation-treated cells, and cells treated with 50µM ligand one hour prior to 2Gy irradiation.
ORGANISM(S): Homo sapiens
SUBMITTER: Vibha Tandon
PROVIDER: E-GEOD-30044 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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