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Gastric cancer: cancer vs. normal, chemoresistance signature that correlates with time to progression of disease

ABSTRACT: microRNA profiling of gastric cancer vs. normal, pre-/-post CF (cisplatin/fluorouracil) chemotherapy. Biopsy samples were collected prior to chemotherapy from 90 gastric cancer patients treated with CF and from 34 healthy volunteers. At the time of disease progression, post-treatment samples were collected from 8 clinical responders. miRNA expression was determined using a custom-designed Agilent microarray. In order to identify an miRNA signature for chemotherapy resistance, we correlated miRNA expression levels with the time to progression (TTP) after CF. 90 pre-treatment gastric cancer samples, 34 healthy volunteers, 8 post-treatment samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Green

PROVIDER: E-GEOD-30070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miRNA signature associated with outcome of gastric cancer patients following chemotherapy.

Kim Chang Hee CH Kim Hark K HK Rettig R Luke RL Kim Joseph J Lee Eunbyul T ET Aprelikova Olga O Choi Il J IJ Munroe David J DJ Green Jeffrey E JE

BMC medical genomics 20111123

<h4>Background</h4>Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA expression is dysregulated in cancer. In order to identify miRNA signatures for gastric cancer and for predicting clinical resistance to cisp ...[more]

PMID: 22112324

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