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Transcription profiling of mouse innate lymphocyte cells lines containing B1-B, NKT, CD8aaT cells and adaptive B2-B, CD4T, CD8abT cells cell-types sorted by FACS

ABSTRACT: Three innate (B1-B, NKT, CD8aaT cells) and adaptive (B2-B, CD4T, CD8abT cells) cell-types were sorted by FACS. Three biological replicates for NKT, CD4T, CD8aaT, CD8abT cells and two biological replicates for B1 and B2 cells were generated and the expression profiles were determined using Affymetrix Mu74Av2 chip. Comparisons between the sample groups allow the identification of genes differentially expressed between the innate and adaptive cell-types. Experiment Overall Design: 3 biological replicates for NKT, CD4T, CD8aaT, CD8abT cells and 2 biological replicates for B1, B2 cells were analyzed

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab

PROVIDER: E-GEOD-3039 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A shared gene-expression signature in innate-like lymphocytes.

Yamagata Tetsuya T Benoist Christophe C Mathis Diane D

Immunological reviews 20060401

Innate and adaptive immunities are the two major arms of the immune system, which rely on distinct cell types. These cells can be distinguished not only by the source of diversity for non-self recognition, of germline or somatic origin, but also by their localization and the pattern and rates of response after encounter of antigenic triggers. In addition, subsets of lymphocytes exist whose receptors require rearrangement but result in semi-invariant structures with a high degree of self-specific ...[more]

PMID: 16623764

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