Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Paolo Provero
PROVIDER: E-GEOD-30513 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
De Vito Claudio C Riggi Nicolo N Cornaz Sandrine S Suvà Mario-Luca ML Baumer Karine K Provero Paolo P Stamenkovic Ivan I
Cancer cell 20120601 6
We have recently demonstrated that human pediatric mesenchymal stem cells can be reprogrammed toward a Ewing sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSCs is shared by embryonic stem cells and CSCs from divergent tumor types. We also provide evidence that the miRNA profile of ESFT CSCs is the result of reversible disruption of TARBP2-dependent miRNA maturation. Restoration of TARBP2 ...[more]