Unknown,Transcriptomics,Genomics,Proteomics

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Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE30652: Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina HT12v3 Gene Expression] GSE30653: Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 27K DNA Methylation] GSE31848: Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 450K DNA Methylation] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Kristopher Nazor 

PROVIDER: E-GEOD-30654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 somatic samples, we identified hPSC-specific epigenetic and transcriptional aberrations in genes subject to X chromosome inactivation (XCI) and genomic imprinting, which were not corrected during direc  ...[more]

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