Viral microRNA expression in two nasal NK T cell lymphoma cell lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Paul Ling
PROVIDER: E-GEOD-30695 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas.
Ramakrishnan Rajesh R Donahue Hart H Garcia David D Tan Jie J Shimizu Norio N Rice Andrew P AP Ling Paul D PD
PloS one 20111110 11
Nasal NK/T cell lymphomas (NKTCL) are a subset of aggressive Epstein-Barr virus (EBV)-associated non-Hodgkin's lymphomas. The role of EBV in pathogenesis of NKTCL is not clear. Intriguingly, EBV encodes more than 40 microRNAs (miRNA) that are differentially expressed and largely conserved in lymphocryptoviruses. While miRNAs play a critical role in the pathogenesis of cancer, especially lymphomas, the expression and function of EBV transcribed miRNAs in NKTCL are not known. To examine the role o ...[more]
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