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Epigenome analysis of normal and cancer tissue from the uterine cervix

ABSTRACT: The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in normal and cancer tissue from the uterine cervix. There are a total of 63 samples, 15 samples of normal histology and 48 cervical cancers. The normal cervical samples were from women who underwent a hysterectomy for uterine fibroids. The 48 cervical cancers were from women who were treated at the Innsbruck Medical University between 1990 and 2006. Bisulphite converted DNA from the 63 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Teschendorff

PROVIDER: E-GEOD-30759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.

Zhuang Joanna J Jones Allison A Lee Shih-Han SH Ng Esther E Fiegl Heidi H Zikan Michal M Cibula David D Sargent Alexandra A Salvesen Helga B HB Jacobs Ian J IJ Kitchener Henry C HC Teschendorff Andrew E AE Widschwendter Martin M

PLoS genetics 20120209 2

Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers. Here we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic tran ...[more]

PMID: 22346766

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