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Gene expression profiling of oral squamous cell carcinoma (OSCC)

ABSTRACT: OSCC is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared the gene expressions of OSCC, oral dysplasia, and normal oral tissue from patients without oral cancer or preneoplastic oral lesions (controls). Results provided models of gene expression to distinguish OSCC from controls. RNA from 167 OSCC, 17 dysplasia and 45 normal oral tissues were extracted and hybridized to Affymetrix U133 2.0 Plus GeneChip arrays. The differentially expressed genes were identified using GenePlus software and the validation was done using RT-PCR, using independent internal and external datasets.

ORGANISM(S): Homo sapiens

SUBMITTER: Chu Chen

PROVIDER: E-GEOD-30784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling identifies genes predictive of oral squamous cell carcinoma.

Chen Chu C Méndez Eduardo E Houck John J Fan Wenhong W Lohavanichbutr Pawadee P Doody Dave D Yueh Bevan B Futran Neal D ND Upton Melissa M Farwell D Gregory DG Schwartz Stephen M SM Zhao Lue Ping LP

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080731 8

Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared the gene expressions of incident primary OSCC, oral dysplasia, and clinically normal oral tissue from surgical patients without head and neck cancer or preneoplastic oral lesions (controls), using Affymetrix U133 2.0 Plus arrays. We identified 131 differentially expressed probe sets using a training set of 119 OSCC pati ...[more]

PMID: 18669583

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