Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xiang Zhou
PROVIDER: E-GEOD-31037 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Joyce Cailin E CE Zhou Xiang X Xia Jing J Ryan Caitriona C Thrash Breck B Menter Alan A Zhang Weixiong W Bowcock Anne M AM
Human molecular genetics 20110801 20
Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying dramatically altered mRNA expression profiles. However, much less is known about the expression of small RNAs. Here, we describe a comprehensive analysis of the normal and psoriatic skin miRNAome with next-generation sequencing in a large patient cohort. We generated 6.7 × 10(8) small RNA reads representing 717 known and 284 putative novel microRNAs (miRNAs). We also observed widespread expression of isomiRs and ...[more]