Dataset Information
Population of viral small RNAs expressed in common marmoset (Callithrix jacchus) T cells latently infected with Herpesvirus saimiri (strain A11)
Ontology highlight
ABSTRACT:
ORGANISM(S): Herpesvirus saimiri (strain 11)
SUBMITTER: Demian Cazalla
PROVIDER: E-GEOD-31065 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A primate herpesvirus uses the integrator complex to generate viral microRNAs.
Molecular cell 20110901 6
Herpesvirus saimiri (HVS) is a γ-herpesvirus that expresses Sm class U RNAs (HSURs) in latently infected marmoset T cells. By deep sequencing, we identified six HVS microRNAs (miRNAs) that are derived from three hairpin structures located immediately downstream of the 3' end processing signals of three of the HSURs. The viral miRNAs associate with Ago proteins and are biologically active. We confirmed that the expression of the two classes of viral noncoding RNAs is linked by identifying chimeri ...[more]
