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Transcription profiling of human plasma cells in muscle in inclusion body myositis and polymyositis

ABSTRACT: Microarray data from muscle biopsy specimens from subjects with inclusion body myositis, polymyositis, and normals Experiment Overall Design: Microarray experiments

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Alan Greenberg

PROVIDER: E-GEOD-3112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Plasma cells in muscle in inclusion body myositis and polymyositis.

Greenberg S A SA Bradshaw E M EM Pinkus J L JL Pinkus G S GS Burleson T T Due B B Bregoli L L O'Connor K C KC Amato A A AA

Neurology 20051201 11

<h4>Background</h4>Previous immunohistochemical studies of muscle from patients with inclusion body myositis and polymyositis found many more T cells than B cells, suggesting a role for intramuscular cell-mediated immune mechanisms rather than humoral mechanisms.<h4>Methods</h4>Microarray studies were performed on muscle biopsy specimens from 40 patients with inclusion body myositis (IBM; n = 23), polymyositis (PM; n = 6), and without neuromuscular disease (n = 11). Reverse transcription PCR of ...[more]

PMID: 16344523

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