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Host cell gene expression in Human respiratory syncytial virus (HRSV) infected mouse macrophage cells at 4, 24 hours post infection

ABSTRACT: We used the microarray data to analyze host cells response on mouse macrophage cells infected with HRSV The HRSV infected mouse macrophage cells were harvested at 4 and 24 hpi and RNA extraction was performed using standard protocol as described by Affymetrix. The aim of this experiment is to analyze host cell response to HRSV infection.

ORGANISM(S): Mus musculus

SUBMITTER: Richard Sugrue

PROVIDER: E-GEOD-31378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A systems-based approach to analyse the host response in murine lung macrophages challenged with respiratory syncytial virus.

Ravi Laxmi Iyer LI Li Liang L Sutejo Richard R Chen Hui H Wong Pui San PS Tan Boon Huan BH Sugrue Richard J RJ

BMC genomics 20130318

<h4>Background</h4>Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in young children. The degree of disease severity is determined by the host response to infection. Lung macrophages play an important early role in the host response to infection and we have used a systems-based approach to examine the host response in RSV-infected lung-derived macrophage cells.<h4>Results</h4>Lung macrophage cells could be efficiently infected (>95%) with RSV in vitro ...[more]

PMID: 23506210

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