Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of different types of cells in murine hair follicle to study cell type-specific gene expression.


ABSTRACT: Hair follicle matrix, outer root sheath, dermal papilla cells and melanocytes and a dermal fraction enriched in fibroblasts were FACS isolated from 4d backskins. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix Mouse Genechip 430A arrays. Comparisons between the sample groups allow the identification of cell-type specific genes. Experiment Overall Design: Mx, ORS, DF, DP and Mc were FACSorted from Lef1-RFP/K14-H2BGFP mice from 4 day old backskins

ORGANISM(S): Mus musculus

SUBMITTER: Michael Rendl 

PROVIDER: E-GEOD-3142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular dissection of mesenchymal-epithelial interactions in the hair follicle.

Rendl Michael M   Lewis Lisa L   Fuchs Elaine E  

PLoS biology 20050920 11


De novo hair follicle formation in embryonic skin and new hair growth in adult skin are initiated when specialized mesenchymal dermal papilla (DP) cells send cues to multipotent epithelial stem cells. Subsequently, DP cells are enveloped by epithelial stem cell progeny and other cell types to form a niche orchestrating hair growth. Understanding the general biological principles that govern the mesenchymal-epithelial interactions within the DP niche, however, has been hampered so far by the lack  ...[more]

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