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Serial gene expression profiling in the liver of Pdgf-c Tg mice that developed hepatic fibrosis and tumors

ABSTRACT: Over expression of PDGF-C in mouse liver resulted in the progression of hepatic fibrosis, steatosis and the development of HCC; this mouse model closely resembles the human HCC that is frequently associated with hepatic fibrosis. Peretinoin (generic name; code, NIK-333), developed by the Kowa Company, (Tokyo, Japan), is an oral acyclic retinoid (ACR) with a vitamin A-like structure that targets the retinoid nuclear receptor. Peretinoin effectively inhibits the progression of hepatic fibrosis and tumors in Pdgf-c Tg mice. Gene expression profiling was evaluated during the progression of hepatic fibrosis and tumors. After weaning at week 4, Pdgf-c Tg or non-transgenic WT mice were fed a basal diet or a diet containing+0.06% peretinoin respectively. At week 20, mice were sacrificed for the analysis of progression of hepatic fibrosis. At week 48, mice were sacrificed for the analysis of the development of hepatic tumors.

ORGANISM(S): Mus musculus

SUBMITTER: Masao Honda 

PROVIDER: E-GEOD-31431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development.

Okada Hikari H   Honda Masao M   Campbell Jean S JS   Sakai Yoshio Y   Yamashita Taro T   Takebuchi Yuuki Y   Hada Kazuhiro K   Shirasaki Takayoshi T   Takabatake Riuta R   Nakamura Mikiko M   Sunagozaka Hajime H   Tanaka Takuji T   Fausto Nelson N   Kaneko Shuichi S  

Cancer research 20120531 17

Hepatocellular carcinoma (HCC) often develops in association with liver cirrhosis, and its high recurrence rate leads to poor patient prognosis. Although recent evidence suggests that peretinoin, a member of the acyclic retinoid family, may be an effective chemopreventive drug for HCC, published data about its effects on hepatic mesenchymal cells, such as stellate cells and endothelial cells, remain limited. Using a mouse model in which platelet-derived growth factor (PDGF)-C is overexpressed (P  ...[more]

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