Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Adam Rosendorff
PROVIDER: E-GEOD-31447 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20110817 20
Endoplasmic reticulum (ER) stress triggers a homeostatic cellular response in mammalian cells to ensure efficient folding, sorting, and processing of client proteins. In lytic-permissive lymphoblastoid cell lines (LCLs), pulse exposure to the chemical ER-stress inducer thapsigargin (TG) followed by recovery resulted in the activation of the EBV immediate-early (BRLF1, BZLF1), early (BMRF1), and late (gp350) genes, gp350 surface expression, and virus release. The protein phosphatase 1 a (PP1a)-sp ...[more]