Unknown,Transcriptomics,Genomics,Proteomics

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SNP data from 82 lung carcinomas and 2 cell lines.

ABSTRACT: SNP profiles from 82 lung carcinomas and 2 cell lines were analyzed to detect potential tumor suppressors in lung cancer. Homozygous deletions revealed two interesting candidates with ARID domains, which were further characterized by sequencing in the whole series. 82 lung carcinomas and 2 cell lines were analyzed with Illumina HumanCNV370-Duo v1.0 chips.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Letouzé 

PROVIDER: E-GEOD-31483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In eukaryotic cells, DNA is packaged into chromatin and this compact storage in the nucleus promotes transcriptional repression of genes. Chromatin remodeling complexes such as the SWI/SNF complex are involved in making DNA accessible to transcription factors and thereby are implicated in the regulation of gene expression. Mutations and altered expression of chromatin remodeling complex genes have been described in cancer cells. Indeed, non-small cell lung cancer cell lines have been shown to ha  ...[more]

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