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Unknown,Transcriptomics,Genomics,Proteomics

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Host cells infected by various types of viruses

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Gallus gallus

SUBMITTER: Richard Sugrue

PROVIDER: E-GEOD-31524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of type I and III interferon signalling pathways occurs in lung epithelial cells infected with low pathogenic avian influenza viruses.

Sutejo Richard R Yeo Dawn S DS Myaing Myint Zu MZ Hui Chen C Xia Jiajia J Ko Debbie D Cheung Peter C F PC Tan Boon-Huan BH Sugrue Richard J RJ

PloS one 20120321 3

The host response to the low pathogenic avian influenza (LPAI) H5N2, H5N3 and H9N2 viruses were examined in A549, MDCK, and CEF cells using a systems-based approach. The H5N2 and H5N3 viruses replicated efficiently in A549 and MDCK cells, while the H9N2 virus replicated least efficiently in these cell types. However, all LPAI viruses exhibited similar and higher replication efficiencies in CEF cells. A comparison of the host responses of these viruses and the H1N1/WSN virus and low passage pH1N1 ...[more]

PMID: 22470468

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