Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Osada Hirotaka
PROVIDER: E-GEOD-31566 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20110819 19
Lung cancers with neuroendocrine (NE) features are often very aggressive but the underlying molecular mechanisms remain elusive. The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that is involved in the pathogenesis of lung cancers with NE features (NE-lung cancers). Here we report the definition of the microRNA miR-375 as a key downstream effector of ASH1 function in NE-lung cancer cells. miR-375 was markedly induced by ASH1 in lung cancer cells where it ...[more]