DNA Methyltransferase 1 and DNA Methylation Patterning Contribute to Germinal Center B-Cell Differentiation

ABSTRACT: We performed DNA methylation (HELP) and gene expression profiling in 17 samples of purified Germinal center B cells (GCBs) and Naive B cells (NBC). We performed supervised analysis using HELP data and defined DNA methylation signature differentiting 2 subgroups of B cvells. Study included purification of human B cells form reactive tonsils, DNA purification and DNA methylation analysis using HELP assay.

ORGANISM(S): Homo sapiens

SUBMITTER: Rita Shaknovich 

PROVIDER: E-GEOD-31671 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress