Mouse kidney arteriolar smooth muscle cells derived from the renin cell lineage: control vs. forskolin treatment to induce renin expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: R. Ariel Gomez
PROVIDER: E-GEOD-31780 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype.
Medrano Silvia S Monteagudo Maria C MC Sequeira-Lopez Maria Luisa S ML Pentz Ellen S ES Gomez R Ariel RA
American journal of physiology. Renal physiology 20111012 1
We have shown that microRNAs (miRNAs) are necessary for renin cell specification and kidney vascular development. Here, we used a screening strategy involving microarray and in silico analyses, along with in situ hybridization and in vitro functional assays to identify miRNAs important for renin cell identity. Microarray studies using vascular smooth muscle cells (SMCs) of the renin lineage and kidney cortex under normal conditions and after reacquisition of the renin phenotype revealed that of ...[more]
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