Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Activation of SREBP in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity


ABSTRACT: Background: Lung function is dependent upon the precise regulation of the synthesis, storage, and catabolism of tissue and alveolar lipids. Results: Activation of SREBP (Sterol Response Element Binding Protein) induced lipogenesis in alveolar epithelial cells, causing neutral lipid accumulation, lung inflammation, and tissue remodeling. Conclusions: The accumulation of neutral lipids in type II epithelial cells and alveolar macrophages caused lung inflammation, consistent with findings in lipid storage disorders. Significance: Pulmonary lipotoxicity may contribute to the pathogenesis of lung dysfunction associated with diabetes, obesity, and other metabolic disorders. Genome-wide transcription profiling comparison between doxycycline-exposed SFTPC-rtTAWT/Tg/(tetO)7CMV-CreWT/Tg/Insig1flox/flox/Insig2-/- mice (i.e., Insig1/2∆/∆ ) and Insig1flox/flox/Insig2-/- . Three independent pooled RNA from isolated lung type 2 cells of each genotype were used.

ORGANISM(S): Mus musculus

SUBMITTER: Yan Xu 

PROVIDER: E-GEOD-31797 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2012-03-01 | GSE31797 | GEO
2011-01-08 | E-GEOD-26496 | biostudies-arrayexpress
2019-09-23 | GSE99577 | GEO
2022-09-22 | GSE213707 | GEO
2010-05-28 | E-GEOD-21754 | biostudies-arrayexpress
2011-01-08 | GSE26496 | GEO
2020-11-10 | GSE157947 | GEO
2018-06-21 | GSE112841 | GEO
2022-05-13 | PXD030672 | Pride
2019-01-25 | GSE125619 | GEO